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Erastin) ( Irreversible inhibitors of GCL, buthionine sulfoxide (BSO) and Cysteine sulfonimide, reduce GSH formation and further inhibit GPX4 activity, promoting ferroptosis alone or enhancing sensitivity to ferroptosis (Yang et al., 2014)

First-line management approaches include: Cold compresses: Apply a clean, cold compress or ice pack wrapped in a thin cloth to the affected area for 10-15 minutes at a time, several times daily during the first 24-48 hours

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